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The surface charge (zeta potential) of strains of Listeria monocytogenes (isogenic mutants of strain EGDe and serotype 1/2a) was determined using microelectrophoresis. Cell envelope hydrophobicity was also determined using the wettability method. The results showed that the mean zeta potential of the strains was between -30 and -10 mV. The strains showed a significantly lower zeta potential at 4 degrees C, but the differences between the strains were small. The hydrophobicity was the lowest for EGDe and the highest for Lm10. The zeta potential and surface hydrophobicity showed a strong correlation, as all strains with a negative zeta potential had a contact angle >80 degrees. This was in contrast to the results of the zeta potential, where the two strains with a contact angle of [Antiangiogenic therapy in the treatment of malignant glioma].
Anti-angiogenic therapy is currently evaluated in the treatment of malignant glioma. In the context of clinical trials, it is based on the assumption that tumor growth is dependent on angiogenesis. This idea is supported by the histological demonstration of abundant microvessels in high-grade gliomas, their correlation with a poor clinical prognosis and the evaluation of tumor volume measurements following treatment of patients with the anti-angiogenic agent SU5416. A number of studies suggest that anti-angiogenic therapy has a beneficial effect in glioma patients. Most of these studies have been conducted with the compound SU5416, and a few with bevacizumab. Further studies of the efficacy of anti-angiogenic therapy in glioma are needed before large-scale, randomized phase III trials can be performed.Find Similar Products by Category
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